Dentin Matrix Acidic Phosphoprotein 1 (DMP1) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
DMP1 Antibody is a Rabbit Polyclonal against DMP1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Dentin Matrix Acidic Phosphoprotein 1 (DMP1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13316 |
| Gene ID | 1758 |
| NCBI Accession | NP_001073380.1, NM_001079911.2, NP_004398.1, NM_004407.3 |
| OMIM | 241520 |
| Background | Antibody anti-DMP1 |
| Status | RUO |
Descripción
Related Products
Human DMP1 (Dentin matrix acidic phosphoprotein 1) ELISA Kit
Ver Producto
Rat DMP1 (Dentin matrix acidic phosphoprotein 1) ELISA Kit
Ver Producto
DMP1 antibody
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.
Ver Producto