DENN Domain Containing Protein 1A (DENND1A) Antibody (FITC)
169€ (20 µg)
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935106861
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name
DENN Domain Containing Protein 1A (DENND1A) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx309062
Description
DENND1A Antibody (FITC) is a Rabbit Polyclonal against DENND1A conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | DENN Domain Containing Protein 1A (DENND1A) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8TEH3 |
| Gene ID | 57706 |
| NCBI Accession | NP_065997.1, NM_020946.1, NP_079096.2, NM_024820.2 |
| OMIM | 613633 |
| Alias | FAM31A,KIAA1608,Connecdenn 1,Connecdenn |
| Background | Antibody anti-DENND1A |
| Status | RUO |
Descripción
DENN domain containing 1A (DENND1A) is a critical guanine nucleotide exchange factor (GEF) for Rab35, a small GTPase involved in endosomal trafficking and membrane recycling. DENND1A regulates the cycling of Rab35 between its GDP-bound inactive form and GTP-bound active state, promoting endosomal sorting and exocytosis. It is particularly important in processes like cytokinesis, where Rab35 facilitates the trafficking of vesicles required for the separation of daughter cells. DENND1A is also implicated in recycling plasma membrane components, such as receptors and transporters, ensuring proper cellular signaling and nutrient uptake. Dysregulation of DENND1A has been linked to pathological conditions, including polycystic ovary syndrome (PCOS), where it may contribute to hormonal imbalances and altered cellular signaling. Its tissue-specific expression, particularly in reproductive and endocrine tissues, underscores its specialized roles in vesicle trafficking and cellular function.
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