DENN domain-containing protein 11 (DENND11) Antibody (Biotin)
260€ (50 µl)
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935106861
info@markelab.com
name
DENN domain-containing protein 11 (DENND11) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx343656
tested applications
ELISA
Description
DENN domain-containing protein 11 (DENND11) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin for the detection of Human LCHN.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | DENN domain-containing protein 11 (DENND11) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Purified by antigen affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Size 3 | 200 µl |
| Size 4 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | A4D1U4 |
| Gene ID | 57189 |
| Alias | LCHN,PRO2561,KIAA1147,Protein LCHN |
| Background | Antibody anti-DENND11 |
| Status | RUO |
Descripción
DENN domain containing 11 (DENND11) is another member of the DENN family, functioning as a guanine nucleotide exchange factor (GEF) for Rab GTPases, with roles in vesicular trafficking and cellular organization. DENND11 is involved in regulating autophagy and endocytosis, contributing to the formation and maturation of autophagosomes and the recycling of endocytic vesicles. The DENN domain facilitates the activation of Rab GTPases by promoting GDP-GTP exchange, thereby modulating vesicular transport and membrane fusion events. DENND11 is highly expressed in certain tissues, particularly those with high vesicle trafficking demands, such as neuronal and epithelial cells. Mutations or dysregulation of DENND11 have been associated with neurological disorders and impaired autophagic flux, highlighting its role in maintaining cellular proteostasis and function.
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