Damage Specific DNA Binding Protein 1 (DDB1) Antibody
442€ (200 µl)
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name
Damage Specific DNA Binding Protein 1 (DDB1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432057
tested applications
P-ELISA, WB, IHC
Description
DDB1 Antibody is a Goat Polyclonal antibody against DDB1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Damage Specific DNA Binding Protein 1 (DDB1) Immunogen: abx269008 - C-Terminus: C-DLIKVVEELTRIH |
| Host | Goat |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/32000, WB: 0.01-2 µg/ml, IHC: 4-6 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 1642, 64470 |
| NCBI Accession | NP_001914.3 |
| Alias | XPE,DDBA,XAP1,XPCE,XPE-BF,UV-DDB1,WHIKERS,UV-damaged DNA-binding factor,DNA damage-binding protein a,DDB p127 subunit |
| Background | Antibody anti-DDB1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Damage-specific DNA binding protein 1 (DDB1) is a critical component of the ubiquitin-proteasome system, serving as a scaffold protein within the CUL4-DDB1 E3 ubiquitin ligase complex. DDB1 interacts with various substrate receptors, including members of the DCAF (DDB1 and CUL4-associated factors) family, to mediate the recognition and ubiquitination of target proteins. Its role is pivotal in regulating DNA repair, particularly nucleotide excision repair (NER), where it facilitates the removal of UV-induced photoproducts and bulky DNA adducts. DDB1 also contributes to the degradation of proteins involved in transcriptional regulation, cell cycle progression, and genome stability. Structurally, DDB1 contains WD40 domains that mediate interactions with CUL4 and substrate receptors, ensuring versatility and specificity in substrate selection. Dysregulation of DDB1 has been associated with genomic instability and cancer development. Its ubiquitous expression highlights its fundamental role in cellular homeostasis and DNA damage response pathways.
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