Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) Antibody
299€ (0.1 mg)
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935106861
info@markelab.com
name
Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx139385
tested applications
IHC, IF/ICC, FCM, IP
Description
CD152 Antibody is a Mouse Monoclonal against CD152.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | FCM: 1-4 µg/ml. Suitable for use in IHC-F, not tested in IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Clone ID | H347 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | IHC, IF/ICC, FCM, IP |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P16410 |
| Gene ID | 1493 |
| Alias | Cytotoxic T-lymphocyte protein 4,CD,GSE,GRD4,ALPS5,CD152,Cytotoxic T-lymphocyte-associated antigen 4,CTLA-4,IDDM12,CELIAC3, |
| Background | Antibody anti-CTLA4 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Cytotoxic T-lymphocyte associated protein 4 (CTLA-4), encoded by the CTLA4 gene on chromosome 2, is an essential immune checkpoint receptor primarily expressed on activated T cells and regulatory T cells (Tregs). CTLA-4 plays a crucial role in maintaining immune homeostasis by delivering inhibitory signals to downregulate T cell activation and proliferation. This receptor functions by binding to the ligands CD80 (B7-1) and CD86 (B7-2), which are expressed on antigen-presenting cells (APCs). By inhibiting excessive immune responses, CTLA-4 prevents autoimmunity and maintains immune tolerance to self-antigens. CTLA-4 is the first immune checkpoint to have been targeted for immunotherapy, exemplified by the development of the monoclonal antibody ipilimumab, which blocks CTLA-4 to boost anti-tumor immune responses. Given its significance in regulating immune responses, CTLA-4 is a focus of research in fields ranging from oncology to autoimmune disorders.
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