Cytoplasmic Aconitate Hydratase (ACO1) Antibody
260€ (50 µl)
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Name
Cytoplasmic Aconitate Hydratase (ACO1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx241082
Tested Applications
ELISA, WB
Description
ACO1 Antibody is a Rabbit Polyclonal against ACO1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Cytoplasmic Aconitate Hydratase (ACO1) Immunogen: Synthetic peptide of human ACO1. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/2000 - 1/10000, WB: 1/1000 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21399 |
| Gene ID | 48 |
| Alias | IRP1,ACONS,HEL60,IREB1,IREBP,IREBP1 |
| Background | Antibody anti-ACO1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Aconitase 1 (ACO1) is a dual-function iron-sulfur protein located in the cytoplasm, acting as both an enzyme and an iron-responsive element-binding protein (IRP1). As an enzyme, ACO1 catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate in the tricarboxylic acid (TCA) cycle, contributing to cellular energy production. Under low iron conditions, ACO1 switches to its role as IRP1, binding to iron-responsive elements (IREs) in mRNAs to regulate the expression of genes involved in iron metabolism, such as ferritin and transferrin receptor. This functional versatility allows ACO1 to coordinate cellular energy metabolism and iron homeostasis. Dysregulation of ACO1 is implicated in disorders related to iron overload or deficiency, as well as oxidative stress-induced damage in neurodegenerative diseases.
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