Cyclin-G-Associated Kinase (GAK) Antibody

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Description
Cyclin-G-Associated Kinase (GAK) Antibody is a monoclonal Nanobody expressed in CHO cells for the detection of Human GAK.
Documents del producto
Product specifications
| Category | Primary Antibodies  | 
| Immunogen Target | Cyclin-G-Associated Kinase (GAK)  | 
| Host | CHO cells  | 
| Reactivity | Human  | 
| Clonality | Monoclonal  | 
| Conjugation | Unconjugated  | 
| Isotype | VHH-8His-Cys-tag  | 
| Clone ID | T350  | 
| Purity | > 95% (SDS-PAGE)  | 
| Purification | Purified by Protein A/G affinity chromatography.  | 
| Size 1 | 100 µg  | 
| Size 2 | 1 mg  | 
| Form | Liquid  | 
| Tested Applications | ELISA, SPR  | 
| Buffer | 0.01 M PBS, pH 7.4.  | 
| Availability | Shipped within 5-12 working days.  | 
| Storage | Store at 4 °C if the entire vial will be used within 1 week. Aliquot and store at -20 °C or -80 °C for long-term storage. Avoid repeated freeze-thaw cycles.  | 
| Dry Ice | No  | 
| UniProt ID | O14976  | 
| Gene ID | 2580  | 
| NCBI Accession | NP_001305063.1  | 
| Background | Antibody anti-GAK  | 
| Status | RUO  | 
| Note | Concentration: 1 mg/ml -  | 
Descripción
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GAK, a member of the Ser/Thr protein kinase family, associates with cyclin G and CDK5. It appears to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. GAK localizes to the perinuclear area and to the trans-Golgi network. It is also observed on the plasma membrane, probably at focals adhesions. Expression is ubiquitous, with highest levels in testis. The protein contains 1 J domain and 1 tensin domain.
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