Cyclin Dependent Kinase Inhibitor 1A / P21 (CDKN1A) Antibody
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Description
Cyclin Dependent Kinase Inhibitor 1A / P21 (CDKN1A) Antibody is a Mouse Monoclonal antibody against p21/WAF1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cyclin Dependent Kinase Inhibitor 1A / P21 (CDKN1A) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | WB, IP |
| Buffer | PBS. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P38936 |
| Background | Antibody anti-CDKN1A |
| Status | RUO |
| Note | Concentration: 1.0 mg/ml - |
Descripción
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CDKN1A antibody
CDKN1A(p21, CIP1, WAF1) is a cyclin-dependent kinase inhibitor. CDKN1A binds to and inhibits the activity of cyclin-CDK2 or-CDK4 complexes, and thus functions as a regulator of cell cycle progression at the G1 phase. The expression of CDKN1A is induced by wild-type but not mutant p53 protein, through which CDKN1A mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. CDKN1A can interact with proliferating cell nuclear antigen(PCNA), and plays a regulatory role in S phase DNA replication and DNA damage repair. CDKN1A was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.
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