Cyclin-Dependent Kinase Inhibitor 1 (CDKN1A) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Cyclin-Dependent Kinase Inhibitor 1 (CDKN1A) Antibody is a Rabbit polyclonal antibody for the detection of Human Cyclin-Dependent Kinase Inhibitor 1 (CDKN1A).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cyclin-Dependent Kinase Inhibitor 1 (CDKN1A) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8 °C for up to 2 weeks. For long-term storage, aliquot and store at -80 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P38936 |
| Gene ID | 1026 |
| NCBI Accession | NP_000380.1 |
| Background | Antibody anti-CDKN1A |
| Status | RUO |
Descripción
Related Products
Human CDKN1A (Cyclin-dependent kinase inhibitor 1) ELISA Kit
Ver Producto
Rat CDKN1A (Cyclin Dependent Kinase Inhibitor 1A) ELISA Kit
Ver Producto
CDKN1A antibody
CDKN1A(p21, CIP1, WAF1) is a cyclin-dependent kinase inhibitor. CDKN1A binds to and inhibits the activity of cyclin-CDK2 or-CDK4 complexes, and thus functions as a regulator of cell cycle progression at the G1 phase. The expression of CDKN1A is induced by wild-type but not mutant p53 protein, through which CDKN1A mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. CDKN1A can interact with proliferating cell nuclear antigen(PCNA), and plays a regulatory role in S phase DNA replication and DNA damage repair. CDKN1A was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.
Ver Producto