Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 2 (CREB3L2) Antibody
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Description
Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 2 (CREB3L2) Antibody is a Rabbit polyclonal antibody for the detection of Human Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 2 (CREB3L2).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 2 (CREB3L2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q70SY1 |
| Gene ID | 64764 |
| NCBI Accession | NP_001240704.1 |
| Background | Antibody anti-CREB3L2 |
| Status | RUO |
Descripción
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Human CREB3L2 (Cyclic AMP-responsive element-binding protein 3-like protein 2) ELISA Kit
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CREB3L2 antibody
Transcription factor involved in unfolded protein response(UPR). In the absence of endoplasmic reticulum(ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes(By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death(PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site(PubMed:17178827).
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