Cyclic AMP-Responsive Element Binding Protein 3 Like Protein 2 (CREB3L2) Antibody
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Description
CREB3L2 Antibody is a Goat Polyclonal antibody against CREB3L2.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cyclic AMP-Responsive Element Binding Protein 3 Like Protein 2 (CREB3L2) |
| Host | Goat |
| Reactivity | Mouse, Rat |
| Recommended Dilution | P-ELISA: 1/16000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 64764, 208647, 362339 |
| NCBI Accession | NP_919047.2 |
| Background | Antibody anti-CREB3L2 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
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Human CREB3L2 (Cyclic AMP-responsive element-binding protein 3-like protein 2) ELISA Kit
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CREB3L2 antibody
Transcription factor involved in unfolded protein response(UPR). In the absence of endoplasmic reticulum(ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes(By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death(PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site(PubMed:17178827).
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