CXADR-Like Membrane Protein (CLMP) Antibody
416€ (200 µl)
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935106861
info@markelab.com
name
CXADR-Like Membrane Protein (CLMP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432515
tested applications
P-ELISA, WB
Description
CLMP Antibody is a Goat Polyclonal antibody against CLMP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CXADR-Like Membrane Protein (CLMP) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/4000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 79827 |
| NCBI Accession | NP_079045.1 |
| Alias | ACAM,ASAM,CSBM,CSBS,Adipocyte adhesion molecule,Coxsackie- and adenovirus receptor-like membrane protein,CAR-like membrane protein |
| Background | Antibody anti-CLMP |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
CLMP is a transmembrane protein belonging to the immunoglobulin superfamily and shares structural similarity with the coxsackie and adenovirus receptor (CXADR). CLMP is widely expressed in epithelial and endothelial tissues, where it contributes to tight junction formation and maintenance of cell polarity. It mediates homophilic adhesion and strengthens intercellular junctions, playing a role in epithelial barrier integrity. Mutations in CLMP have been linked to congenital short bowel syndrome, a rare developmental disorder characterized by reduced intestinal length due to impaired embryonic gut elongation. CLMP is thought to regulate cellular signaling pathways that influence proliferation and differentiation during organogenesis. In addition to its developmental roles, CLMP has been implicated in regulating vascular permeability and may contribute to immune cell trafficking in inflammatory conditions. Structurally, CLMP contains extracellular immunoglobulin-like domains that mediate adhesion and intracellular domains that interact with cytoskeletal proteins to stabilize cell-cell junctions. Dysregulation of CLMP expression has been observed in certain cancers, suggesting a potential role in tumor progression and metastasis. Current research focuses on understanding its signaling mechanisms and exploring its therapeutic potential in tissue repair and developmental disorders.
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