Cullin 2 (CUL2) Antibody
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Description
CUL2 Antibody is a Rabbit Polyclonal against CUL2.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cullin 2 (CUL2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13617 |
| Gene ID | 8453 |
| Background | Antibody anti-CUL2 |
| Status | RUO |
Descripción
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CUL2 antibody
Core component of multiple cullin-RING-based ECS(ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1(By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor(HIF).
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Cullin 2 (CUL2) Antibody
Cullin 2 Antibody is a Rabbit Polyclonal antibody against Cullin 2. Cullin 2 is a core component of multiple cullin-RING-based ECS (ElonginB/C-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. It serves as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
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Cullin 2 (CUL2) Antibody
Cullin 2 Antibody is a Rabbit Polyclonal Antibody against Cullin 2.
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