Cow Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 (UCH-L1) ELISA Kit

Este producto es parte de UCHL - Ubiquitin C-Terminal Hydrolase L
Cow Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 (UCH-L1) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

687.5€ (96 tests)

Elisa Kits UCHL1

proveedor

Abbexa

reference

abx518305

Tested Applications

ELISA

reactivity

Cow

status

RUO

clonality

Descripción

Cow Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 (UCH-L1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Cow Ubiquitin carboxyl-terminal hydrolase isozyme L1 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

UCHL1 is a deubiquitinating enzyme that cleaves ubiquitin from protein substrates, playing a pivotal role in the ubiquitin-proteasome system (UPS). UCHL1 is highly expressed in neurons and is crucial for maintaining protein homeostasis, axonal transport, and synaptic function. It regulates the degradation of misfolded proteins, ensuring neuronal survival and preventing neurotoxicity. Mutations in UCHL1 are linked to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease due to impaired protein turnover and accumulation of toxic aggregates. It also has oncogenic and tumor-suppressive roles depending on the cellular context, regulating cell cycle progression and apoptosis. Knockout studies in mice show progressive neurodegeneration, motor dysfunction, and impaired synaptic activity, highlighting UCHL1’s critical role in neuronal maintenance, proteostasis, and neuroprotection.

Características del producto

category

ELISA Kits


immunogen target

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 (UCH-L1)


reactivity

Cow


test range

0.156 ng/ml - 10 ng/ml


assay data

Quantitative


detection method

Colorimetric


sample type

Tissue homogenates,Cell lysates,Other biological fluids


size 1

96 tests


alias

HEL-117,HEL-S-53,NDGOA,PARK5 PGP 9.5,PGP9.5,PGP95,SPG79,SPG79A,UCHL-1 Uch-L1,Neuron cytoplasmic protein 9.5,Ubiquitin thioesterase L1


storage

Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit


or code

UCHL1


dry ice

No


note

This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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