Cow Transferrin (TF) Protein
351€ (50 µg)
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name
Cow Transferrin (TF) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx069408
tested applications
WB, SDS-PAGE
Description
Recombinant Transferrin (TRF) is a recombinant Cow protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Transferrin (TRF) |
| Host | E. coli |
| Origin | Cow |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 36.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp284-Ala575 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 500 µg |
| Size 5 | 1 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q29443 |
| Alias | PRO1557,PRO2086,TFQTL1,HEL-S-71p |
| Background | Protein TF |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Transferrin (TF) is a glycoprotein that plays a central role in iron homeostasis by binding and transporting iron ions in the blood to various tissues, including the liver, bone marrow, and brain. It interacts with transferrin receptors (TFR1 and TFR2) on cell surfaces to mediate iron uptake through receptor-mediated endocytosis, ensuring iron availability for critical cellular processes such as hemoglobin synthesis, DNA replication, and energy metabolism. TF is produced primarily in the liver and is widely distributed in blood plasma. Dysregulation of transferrin leads to iron-related disorders, such as anemia, iron overload (hemochromatosis), and neurodegenerative diseases like Alzheimer’s, where altered iron metabolism contributes to oxidative stress and neuronal damage. Elevated transferrin levels are also associated with liver disease and systemic inflammation. Knockout studies demonstrate impaired iron transport, reduced erythropoiesis, and disrupted metabolic processes, emphasizing its essential role in systemic iron regulation, cellular function, and red blood cell production.
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