Cow Tissue Factor (TF) Protein

Este producto es parte de F3 - coagulation factor III, tissue factor
Cow Tissue Factor (TF) Protein

Pida mas información

935106861

info@markelab.com

Precio

416€ (50 µg)

Protein F3

proveedor

Abbexa

reference

abx166277

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Tissue Factor Protein is a recombinant Cow protein expressed in E. coli.


Background

Coagulation Factor III, also known as Tissue Factor (F3), is a critical glycoprotein in the initiation of the extrinsic pathway of the coagulation cascade. It acts as a receptor and cofactor for Factor VIIa, forming a complex that activates Factor X, which in turn leads to thrombin generation and clot formation. Tissue Factor is highly expressed in subendothelial tissues and is exposed upon vascular injury, where it serves as the primary trigger for hemostasis. Beyond its role in coagulation, F3 also participates in various signaling pathways, influencing inflammation, angiogenesis, and cancer progression through its interaction with protease-activated receptors (PARs). Dysregulation of Tissue Factor expression is associated with pathological conditions such as thrombosis, atherosclerosis, and malignancies. The study of F3 and its interactions, including its structure and binding properties, is crucial for developing targeted anticoagulant therapies and understanding its role in disease mechanisms. Its activity is often analyzed using advanced biochemical assays to elucidate its functions in both normal and pathological states.

Características del producto

category

Proteins and Peptides


origin

Cow


host

E. coli


immunogen target

Tissue Factor (TF)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

50 µg


size 2

100 µg


size 3

200 µg


size 4

500 µg


size 5

1 mg


observerd MW

Molecular Weight: Calculated MW: 32.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr36-Ala292 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

F3


dry ice

No


availability

Shipped within 5-7 working days.


alias

TF,TFA,CD142,Coagulation factor III,Thromboplastin


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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