Cow Tissue Factor (TF) Protein

Pida mas información
935106861
info@markelab.com
Precio
416€ (50 µg)
Protein F3
proveedor
Abbexareference
abx166277Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Tissue Factor Protein is a recombinant Cow protein expressed in E. coli.
Background
Coagulation Factor III, also known as Tissue Factor (F3), is a critical glycoprotein in the initiation of the extrinsic pathway of the coagulation cascade. It acts as a receptor and cofactor for Factor VIIa, forming a complex that activates Factor X, which in turn leads to thrombin generation and clot formation. Tissue Factor is highly expressed in subendothelial tissues and is exposed upon vascular injury, where it serves as the primary trigger for hemostasis. Beyond its role in coagulation, F3 also participates in various signaling pathways, influencing inflammation, angiogenesis, and cancer progression through its interaction with protease-activated receptors (PARs). Dysregulation of Tissue Factor expression is associated with pathological conditions such as thrombosis, atherosclerosis, and malignancies. The study of F3 and its interactions, including its structure and binding properties, is crucial for developing targeted anticoagulant therapies and understanding its role in disease mechanisms. Its activity is often analyzed using advanced biochemical assays to elucidate its functions in both normal and pathological states.
Características del producto
category
Proteins and Peptides
origin
Cow
host
E. coli
immunogen target
Tissue Factor (TF)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
50 µg
size 2
100 µg
size 3
200 µg
size 4
500 µg
size 5
1 mg
observerd MW
Molecular Weight: Calculated MW: 32.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr36-Ala292 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
F3
dry ice
No
availability
Shipped within 5-7 working days.
alias
TF,TFA,CD142,Coagulation factor III,Thromboplastin
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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