Cow Muscarinic acetylcholine receptor M3 (CHRM3) ELISA Kit

Este producto es parte de CHRM - Muscarinic acetylcholine receptor
Cow Muscarinic acetylcholine receptor M3 (CHRM3) ELISA Kit
715€ (96 tests)

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Name
Cow Muscarinic acetylcholine receptor M3 (CHRM3) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx518578
Tested Applications
ELISA

Description

Cow Muscarinic acetylcholine receptor M3 (CHRM3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Cow Muscarinic Acetylcholine Receptor M3 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Muscarinic acetylcholine receptor M3 (CHRM3)
Reactivity
Cow
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-12 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
P41984
Alias
CHRM3,Chrm-3,M3R,cholinergic receptor, muscarinic 3,cholinergic receptor,cholinergic receptor, muscarinic 3, cardiac,M3 receptor,HM3, PBS, EGBRS, m3AChR
Background
Elisa Kits for: CHRM3
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

CHRM3 encodes the cholinergic receptor muscarinic 3, another receptor in the muscarinic acetylcholine receptor family that primarily couples to Gq/11 proteins. Upon activation by acetylcholine, CHRM3 stimulates phospholipase C (PLC), leading to increased production of inositol triphosphate (IP3) and diacylglycerol (DAG), which together elevate intracellular calcium ion concentrations and activate downstream signaling pathways. CHRM3 is abundantly expressed in smooth muscle tissues of the gastrointestinal tract, bladder, and lungs, where it plays a key role in mediating smooth muscle contraction. It is critical for processes such as gastrointestinal motility, bronchoconstriction, and urinary bladder contraction. In the CNS, CHRM3 contributes to cognitive function and neuronal signaling. Dysregulation of CHRM3 has been implicated in disorders like overactive bladder syndrome, asthma, and certain types of cancer. Pharmacologically, CHRM3 antagonists, such as antimuscarinics, are used to treat conditions like overactive bladder, while agonists could be explored for potential use in cognitive enhancement. CHRM3 remains a critical target for both autonomic regulation and emerging therapies in neurological disorders and cancer research.

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