Cow Matrix Metalloproteinase 13 (MMP13) Protein
proveedor
Abbexareference
abx654292Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Cow Matrix Metalloproteinase 13 (MMP13) Protein is a Recombinant Cow protein expressed in E. coli.
Background
MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. Collagenase 3, also known as MMP-13, is an enzyme encoded by the MMP13 gene in humans. It is also recognized by its aliases CLG3, MANDP1, and MDST. MMP-13 is particularly efficient at cleaving type II collagen, more so than types I and III. It is thought to be involved in the turnover of articular cartilage and is associated with the pathophysiology of osteoarthritis. The activity of MMP-13 is tightly regulated due to its potent proteolytic capabilities. Various cytokines and growth factors have been shown to influence the expression of the Mmp13 gene, including parathyroid hormone, IGF-1, TGF-β, hepatocyte growth factor, as well as several inflammatory cytokines such as IL-1α and IL-1β.
Características del producto
category
Proteins and Peptides
origin
Cow
host
E. coli
immunogen target
Matrix Metalloproteinase 13 (MMP13)
host
E. coli
conjugation
Unconjugated
form
Lyophilized
tested applications
WB, SDS-PAGE
size 1
50 µg
size 2
100 µg
size 3
200 µg
size 4
1 mg
size 5
5 mg
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
MMP13
dry ice
No
availability
Shipped within 5-7 working days.
note
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
Quizá le pueda interesar
Matrix Metalloproteinase 13 (MMP13) Antibody
proveedor
Abbexareference
abx102907Tested Applications
WB, IHC, IF/ICCreactivity
Humanstatus
RUOclonality
PolyclonalPolyclonal Antibody to Matrix Metalloproteinase 13 (MMP13).
250€ (100 µl)
Ver másRat Matrix Metalloproteinase 13 / Collagenase 3 (MMP13) CLIA Kit
proveedor
Abbexareference
abx196026Tested Applications
CLIAreactivity
Ratstatus
RUORat Matrix Metalloproteinase 13 (MMP-13) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA...
618.75€ (96 tests)
Ver másDog Matrix Metalloproteinase 13 (MMP13) Protein
proveedor
Abbexareference
abx654293Tested Applications
WB, SDS-PAGEstatus
RUODog Matrix Metalloproteinase 13 (MMP13) Protein is a Recombinant Dog protein expressed in E. coli.
2112.5€ (1 mg)
Ver más