Cow Breast Cancer Type 1 Susceptibility Protein (BRCA1) ELISA Kit
715€ (96 tests)
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Name
Cow Breast Cancer Type 1 Susceptibility Protein (BRCA1) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx514412
Tested Applications
ELISA
Description
Cow Breast Cancer Type 1 Susceptibility Protein (BRCA1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Cow Breast cancer type 1 susceptibility protein homolog concentrations in tissue homogenates, cell lysates and other biological fluids.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Immunogen Target | Breast Cancer Type 1 Susceptibility Protein (BRCA1) |
| Reactivity | Cow |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q864U1 |
| Alias | BRCAI,BRCC1,BROVCA1,FANCS IRIS,PNCA4,PPP1R53,PSCP,RNF53,RING finger protein 53 |
| Background | Elisa Kits for: BRCA1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Background
BRCA1 is a tumor suppressor protein that plays a central role in maintaining genomic stability through its involvement in DNA damage repair, cell cycle regulation, and transcriptional control. BRCA1 functions as part of the homologous recombination repair pathway, where it recognizes and repairs double-strand DNA breaks, ensuring genomic integrity during cell division. It forms complexes with other DNA repair proteins, including RAD51, BARD1, and BRCA2, to facilitate accurate repair processes. BRCA1 also regulates cell cycle checkpoints, particularly at the G2/M phase, to prevent the propagation of damaged DNA. It is widely expressed in proliferative tissues, including breast and ovarian tissue, where its loss or mutation is associated with increased susceptibility to breast, ovarian, and other cancers. Mutations in BRCA1 disrupt its DNA repair function, leading to chromosomal instability, accumulation of mutations, and tumorigenesis. BRCA1 also interacts with signaling pathways involved in apoptosis, transcriptional regulation, and immune response, further highlighting its multifaceted role in cellular homeostasis. Knockout studies reveal defective DNA repair, increased tumorigenesis, and impaired cell cycle control, underscoring BRCA1’s critical function in DNA repair, tumor suppression, and genomic stability.
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