Cow Atrial Natriuretic Peptide Receptor 2 (NPR2) ELISA Kit

Product specifications

ELISA Kits

Atrial Natriuretic Peptide Receptor 2 (NPR2)

Cow

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-12 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

P46197

GCB,AMD1,AMDM; ANPb,ECDM,GC-B,NPRB,SNSK,ANPRB,GUC2B,NPRBi,GUCY2B,Guanylate cyclase B,GC-B,Atrial natriuretic peptide receptor type B

Elisa kits for NPR2

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

NPR2, also known as guanylyl cyclase-B, primarily binds C-type natriuretic peptide (CNP), a critical regulator of skeletal growth and bone homeostasis. Similar to NPR1, NPR2 activation leads to cGMP production, which modulates cellular processes such as chondrocyte proliferation, bone elongation, and vascular relaxation. NPR2 is highly expressed in growth plate chondrocytes, vascular smooth muscle cells, and the nervous system. Loss-of-function mutations in NPR2 are associated with skeletal dysplasias, such as acromesomelic dysplasia type Maroteaux, characterized by short stature and abnormal bone growth. In the vascular system, NPR2-mediated CNP signaling contributes to endothelial repair and inhibition of vascular smooth muscle proliferation, playing a protective role in cardiovascular health. NPR2 undergoes dimerization and ligand-induced conformational changes to activate its guanylyl cyclase domain, and its activity is modulated by post-translational modifications such as phosphorylation. Research indicates that NPR2 plays an essential role in embryonic development and that its dysregulation may impact tissue regeneration and repair processes. Pharmacological activation of NPR2 has been explored for treating conditions like dwarfism and vascular dysfunction, emphasizing its potential as a therapeutic target.

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