Cow Activin A Receptor Type 2A (ACVR2A) Protein
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Description
Recombinant Activin A Receptor Type II A (ACVR2A) is a recombinant Cow protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Activin A Receptor Type 2A (ACVR2A) |
| Host | E. coli |
| Origin | Cow |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 16.8 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu192-Ser325 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 500 µg |
| Size 5 | 1 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q28043 |
| Alias | ACVR2,Activin receptor type II,ACTR-IIA |
| Background | Protein ACVR2A |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ACVR2A is a type II receptor that binds activin ligands and subsequently activates type I receptors like ACVR1B. This receptor is integral to TGF-β/activin signaling, mediating cellular processes like growth, differentiation, and apoptosis. ACVR2A is expressed in various tissues, particularly in the reproductive system. Mutations or loss of ACVR2A function are implicated in cancers such as colorectal carcinoma, where its absence disrupts normal cell cycle control and promotes tumor progression.
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