COP9 signalosome complex subunit 3 (COPS3) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
COP9 signalosome complex subunit 3 (COPS3) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human COPS3.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | COP9 signalosome complex subunit 3 (COPS3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, FCM: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UNS2 |
| Gene ID | 8533 |
| OMIM | 604665 |
| Background | Antibody anti-COPS3 |
| Status | RUO |
Descripción
Related Products
COPS3 antibody
Component of the COP9 signalosome complex(CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin(Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Ver Producto
COP9 Signalosome Subunit 3 (COPS3) Antibody
COPS3 Antibody is a Rabbit Polyclonal antibody against COPS3. The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
Ver Producto
COP9 Signalosome Subunit 3 (COPS3) Antibody
Cop9 Constitutive Photomorphogenic Homolog Subunit 3 (Arabidopsis) Antibody is a Rabbit Polyclonal antibody against Cop9 Constitutive Photomorphogenic Homolog Subunit 3 (Arabidopsis).
Ver Producto