Complement C3 (C3) Antibody (FITC)

Pida mas información
935106861
info@markelab.com
Precio
169€ (20 µg)
Antibody anti-C3
proveedor
Abbexareference
abx106701Tested Applications
reactivity
Mousestatus
RUOclonality
PolyclonalDescripción
Complement C3 (C3) Antibody (FITC) is a Rabbit Polyclonal antibody conjugated to FITC against Complement C3. C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
Background
Complement C3 is a central component of the complement system, an essential part of the innate immune response that aids in the clearance of pathogens and the regulation of inflammation C3 is involved in all three complement pathways (classical, alternative, and lectin), playing a critical role in immune defense by promoting opsonization, cell lysis, and inflammation activation Upon cleavage into C3a and C3b, C3a acts as an inflammatory mediator, and C3b binds to pathogens to mark them for destruction by phagocytes Complement C3 deficiency or dysfunction is associated with various autoimmune diseases, such as systemic lupus erythematosus (SLE), and with susceptibility to infections C3 is also involved in the regulation of adaptive immunity, influencing antibody production and T-cell responses Its role in inflammation, pathogen clearance, and immune system regulation highlights its importance in maintaining immune balance and tissue homeostasis
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Mouse
immunogen target
Complement C3 (C3)
host
Rabbit
isotype
IgG
conjugation
FITC
form
Liquid
purity
> 95%
purification
Purified by Protein G.
recommended dilution
Optimal dilutions/concentrations should be determined by the end user.
buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
size 1
20 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
1 mg
storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
or code
C3
dry ice
No
availability
Shipped within 5-10 working days.
alias
ASP,C3a,C3b,AHUS5,ARMD9,CPAMD1,HEL-S-62p,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
uniprot id
NCBI accession
NP_033908.2, NM_009778.3
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