Colony Stimulating Factor Receptor, Granulocyte (CSF3R) Antibody
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Description
CSF3R Antibody is a Rabbit Polyclonal against CSF3R.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Colony Stimulating Factor Receptor, Granulocyte (CSF3R) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q99062 |
| Gene ID | 1441 |
| Alias | SCN7,CD114,GCSFR,Granulocyte colony-stimulating factor receptor,G-CSF receptor,G-CSF-R |
| Background | Antibody anti-CSF3R |
| Status | RUO |
Descripción
The Colony-Stimulating Factor 3 Receptor (CSF3R), also known as the granulocyte colony-stimulating factor receptor (G-CSFR), is a transmembrane protein that plays a crucial role in the regulation of granulopoiesis—the process by which granulocytes, a type of white blood cell, are produced in the bone marrow. CSF3R is the receptor for colony-stimulating factor 3 (CSF3 or G-CSF), a cytokine that promotes the proliferation, differentiation, and activation of granulocytic progenitors and mature neutrophils. It is a member of the cytokine receptor family and shares structural and functional similarities with other receptors in this family. The CSF3R gene is located on chromosome 1 (1p34.3) and encodes the G-CSFR protein. CSF3R is essential for neutrophil production and function and is involved in the immune response against infections, particularly bacterial infections. Dysregulation or mutations in the CSF3R gene have been implicated in a variety of hematological disorders, including severe congenital neutropenia and certain types of acute myeloid leukemia (AML), where it often plays a role in leukemic transformation.
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