Colony Stimulating Factor 2 Receptor Alpha (CSF2RA) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
Colony Stimulating Factor 2 Receptor Alpha (CSF2RA) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx212372
tested applications
ELISA, WB
Description
CSF2RA Antibody is a Rabbit Polyclonal against CSF2RA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Colony Stimulating Factor 2 Receptor Alpha (CSF2RA) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/1000 - 1/5000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P15509 |
| Gene ID | 1438 |
| Alias | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha,GMR,CD116,CSF2R,SMDP4,CDw116,CSF2RX,CSF2RY,GMCSFR,CSF2RAX,CSF2RAY,alphaGMR,GMR-alpha,GMCSFR-alpha,GM-CSF-R-alpha |
| Background | Antibody anti-CSF2RA |
| Status | RUO |
Descripción
Colony stimulating factor 2 receptor subunit alpha (CSF2RA) is a protein that serves as part of the receptor complex for granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine critical for the growth, differentiation, and function of granulocytes and macrophages. This receptor subunit is primarily expressed on the surface of myeloid lineage cells, including neutrophils, monocytes, and macrophages, as well as on some non-hematopoietic tissues. CSF2RA forms a heterodimer with the common beta chain (CSF2RB) to mediate the signaling of GM-CSF, which activates pathways such as JAK/STAT, MAPK, and PI3K, driving cell proliferation, survival, and activation. Dysregulation of CSF2RA signaling has been associated with conditions like inflammatory diseases, including rheumatoid arthritis and asthma, as well as hematological malignancies such as leukemia. Mutations or deletions in the CSF2RA gene can impair immune responses and are linked to congenital disorders like surfactant metabolism dysfunction in the lung. Given its role in immune modulation, CSF2RA is being explored as a therapeutic target in cancer immunotherapy and inflammatory conditions, aiming to modulate the activity of GM-CSF and its downstream effects. Understanding its molecular mechanisms continues to provide insights into immune regulation and potential clinical interventions.
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CSF2RA Antibody is a Rabbit Polyclonal antibody against CSF2RA. The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008].
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