Cluster of Differentiation 99 (CD99) Antibody (FITC)
364€ (100 tests)
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Name
Cluster of Differentiation 99 (CD99) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx139743
Tested Applications
FCM
Description
CD99 Antibody is a Mouse Monoclonal against CD99.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Cluster of Differentiation 99 (CD99) Immunogen: Human Thymocytes. |
| Host | Mouse |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | FCM: 4 µl/100 µl of whole blood or 106 cells. Optimal dilutions/concentrations should be determined by the end user.The content of a vial (0.4 ml) is sufficient for 100 tests. |
| Clonality | Monoclonal |
| Conjugation | FITC |
| Isotype | IgG2a Kappa |
| Clone ID | P208 |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P14209 |
| Gene ID | 4267 |
| Alias | Xg blood group,MIC2,HBA71,MIC2X,MIC2Y,MSK5X,Protein MIC2,T-cell surface glycoprotein E2 |
| Background | Antibody anti-CD99 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD99, also known as MIC2, is a cell surface glycoprotein expressed on various cell types, including leukocytes, endothelial cells, and certain tumor cells. The CD99 protein plays a role in multiple biological processes, such as cell adhesion, migration, apoptosis, and immune regulation. CD99 expression is crucial in thymocyte differentiation and T cell activation, as well as in leukocyte extravasation, where immune cells move from blood vessels to sites of inflammation. It is also involved in neural cell adhesion and spermatogenesis, highlighting its diverse functional roles across cell types and tissues. CD99 has garnered attention for its clinical implications, especially in cancer, as it is overexpressed in Ewing sarcoma and other tumors, making it a biomarker of diagnostic and therapeutic interest. Additionally, CD99 is involved in the immune response, where it contributes to the regulation of leukocyte activity and inflammation. The molecule also plays a role in apoptosis, promoting cell death in specific contexts, and has a dual role in tumor biology, both enhancing and inhibiting tumor progression depending on the cancer type and tissue context.
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