Cluster Of Differentiation 5 Phospho-Tyr453 (CD5 pY453) Antibody
221€ (50 µg)
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935106861
info@markelab.com
name
Cluster Of Differentiation 5 Phospho-Tyr453 (CD5 pY453) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx329304
tested applications
ELISA, WB, IHC, IF/ICC
Description
CD5 (pY453) Antibody is a Rabbit Polyclonal against CD5 (pY453).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cluster Of Differentiation 5 Phospho-Tyr453 (CD5 pY453) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Data | Modification: Phosphorylation // Target Modification: Tyr453 |
| Recommended Dilution | ELISA: 1/20000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P06127 |
| Gene ID | 921 |
| Alias | T1,LEU1,T-cell surface glycoprotein CD5,Lymphocyte antigen T1/Leu-1 |
| Background | Antibody anti-CD5 |
| Status | RUO |
Descripción
The CD5 molecule is a type I transmembrane glycoprotein primarily expressed on the surface of T cells and a subset of B cells known as B1a cells. CD5 functions as an immunomodulatory receptor, playing a critical role in T-cell activation, immune tolerance, and B-cell signaling. Its primary role is in regulating immune responses by controlling the threshold of antigen receptor signaling in both T and B cells. CD5 is also involved in maintaining the delicate balance between immune activation and immune tolerance, which prevents autoimmune responses while ensuring effective immunity. CD5 belongs to the scavenger receptor cysteine-rich (SRCR) superfamily of receptors, a group of molecules known to be involved in diverse biological functions, including immunity, apoptosis, and cellular adhesion. CD5 is especially notable for its role as a negative regulator of T-cell receptor (TCR) and B-cell receptor (BCR) signaling. This regulatory capacity makes CD5 crucial in maintaining immune homeostasis.
