Cholinergic Receptor, Muscarinic 3 (CHRM3) Antibody
273€ (100 µl)
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935106861
info@markelab.com
name
Cholinergic Receptor, Muscarinic 3 (CHRM3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx175851
tested applications
WB, IHC, IF/ICC
Description
Cholinergic Receptor, Muscarinic 3 (CHRM3) Antibody is a Rabbit Polyclonal antibody against Cholinergic Receptor, Muscarinic 3 (CHRM3).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cholinergic Receptor, Muscarinic 3 (CHRM3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CHRM3,Chrm-3,M3R,cholinergic receptor, muscarinic 3,cholinergic receptor,cholinergic receptor, muscarinic 3, cardiac,M3 receptor,HM3, PBS, EGBRS, m3AChR |
| Background | Antibody anti-CHRM3 |
| Status | RUO |
Descripción
CHRM3 encodes the cholinergic receptor muscarinic 3, another receptor in the muscarinic acetylcholine receptor family that primarily couples to Gq/11 proteins. Upon activation by acetylcholine, CHRM3 stimulates phospholipase C (PLC), leading to increased production of inositol triphosphate (IP3) and diacylglycerol (DAG), which together elevate intracellular calcium ion concentrations and activate downstream signaling pathways. CHRM3 is abundantly expressed in smooth muscle tissues of the gastrointestinal tract, bladder, and lungs, where it plays a key role in mediating smooth muscle contraction. It is critical for processes such as gastrointestinal motility, bronchoconstriction, and urinary bladder contraction. In the CNS, CHRM3 contributes to cognitive function and neuronal signaling. Dysregulation of CHRM3 has been implicated in disorders like overactive bladder syndrome, asthma, and certain types of cancer. Pharmacologically, CHRM3 antagonists, such as antimuscarinics, are used to treat conditions like overactive bladder, while agonists could be explored for potential use in cognitive enhancement. CHRM3 remains a critical target for both autonomic regulation and emerging therapies in neurological disorders and cancer research.
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