Chicken Transforming Growth Factor Beta 1 (TGFb1) Protein

Este producto es parte de TGFB- Transforming Growth Factor Beta
Chicken Transforming Growth Factor Beta 1 (TGFb1) Protein

Pida mas información

935106861

info@markelab.com

Precio

429€ (50 µg)

Protein TGFB1

proveedor

Abbexa

reference

abx069422

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Chicken Transforming Growth Factor Beta 1 (TGFb1) is a recombinant Chicken protein produced in a Prokaryotic expression system (E. coli).


Background

TGFB1 is a multifunctional cytokine that belongs to the transforming growth factor beta (TGF-β) family, which regulates cell proliferation, differentiation, apoptosis, and immune responses. TGFB1 is secreted as a latent complex that is activated in response to tissue injury, hypoxia, or cellular stress, enabling it to bind to its receptors and initiate downstream SMAD-dependent and non-SMAD signaling pathways. TGFB1 is a critical regulator of tissue homeostasis, embryonic development, and immune tolerance, where it suppresses inflammatory responses and promotes regulatory T cell (Treg) differentiation. In wound healing, TGFB1 induces extracellular matrix production and fibroblast activation, facilitating tissue repair and fibrosis. However, dysregulated TGFB1 signaling contributes to cancer progression by promoting epithelial-mesenchymal transition (EMT), immune evasion, and metastasis. It also drives fibrosis in chronic diseases, including pulmonary fibrosis and liver cirrhosis. Knockout studies reveal severe developmental defects, immune dysregulation, and impaired tissue repair, underscoring TGFB1's essential roles in cellular communication, immune modulation, and tissue remodeling.

Características del producto

category

Proteins and Peptides


origin

Chicken


host

E. coli


immunogen target

Transforming Growth Factor Beta 1 (TGFb1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

50 µg


size 2

100 µg


size 3

200 µg


size 4

500 µg


size 5

1 mg


observerd MW

Molecular Weight: Calculated MW: 16.7 kDa Observed MW (SDS-PAGE): 18 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp260-Ser373 Tag: N-terminal His tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

TGFB1


dry ice

No


availability

Shipped within 5-12 working days.


alias

CED,DPD1,IBDIMDE LAP,TGF-beta1,TGFB,TGFbeta


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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