Chemokine C-C-Motif Receptor 10 (CCR10) Antibody (Biotin)
169€ (20 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Chemokine C-C-Motif Receptor 10 (CCR10) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx316802
Tested Applications
ELISA
Description
CCR10 Antibody (Biotin) is a Rabbit Polyclonal against CCR10 conjugated to Biotin.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Chemokine C-C-Motif Receptor 10 (CCR10) Immunogen: Recombinant Human C-C chemokine receptor type 10 protein (314-362AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P46092 |
| Gene ID | 2826 |
| OMIM | 600240 |
| Alias | CCR10,C-C motif chemokine receptor 10,GPR-2 |
| Background | Antibody anti-CCR10 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
C-C Chemokine Receptor Type 10 (CCR10) is a G-protein-coupled receptor (GPCR) that binds to two chemokine ligands: CCL27 and CCL28. CCR10 plays a pivotal role in skin and mucosal immunity, primarily regulating the migration of T lymphocytes and other immune cells to tissues such as the epidermis and mucosal surfaces. Its ligand CCL27 is highly expressed in keratinocytes, promoting homing of CCR10-expressing T cells to the skin, which is essential for maintaining cutaneous immune surveillance. This mechanism is also involved in inflammatory skin diseases such as psoriasis and atopic dermatitis, where excessive T-cell recruitment to the skin contributes to chronic inflammation and tissue damage. On the other hand, CCL28 expression is upregulated in mucosal tissues like the respiratory and gastrointestinal tracts, guiding immune cells expressing CCR10 to these sites to protect against pathogens. CCR10 is highly relevant in the context of allergic diseases, autoimmune skin conditions, and cancer, where dysregulated expression enables tumor cells to evade immune responses or promote metastasis. In cancers, such as melanoma and breast cancer, CCR10 has been associated with tumor progression due to its role in immune cell trafficking and metastasis to skin and mucosal tissues. CCR10 is also a potential target for immunotherapy, as inhibiting its signaling pathway could reduce chronic inflammation or prevent tumor immune escape. Thus, CCR10 is a critical chemokine receptor bridging immunity, inflammation, and oncology, making it a promising candidate for therapeutic interventions.
Productos relacionados
Chemokine C-C-Motif Receptor 10 (CCR10) Antibody
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate c…
Ver producto
Mouse C-C Chemokine Receptor Type 10 (CCR10) ELISA Kit
Mouse C-C Chemokine Receptor Type 10 (CCR10) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mous…
Ver producto
Chemokine C-C-Motif Receptor 10 (CCR10) Antibody
CCR10 Antibody is a Rabbit Polyclonal against CCR10.…
Ver producto