Cellular Tumor Antigen P53 (TP53) Antibody (Biotin)

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Description
p53 Antibody (Biotin) is a Rabbit Polyclonal against p53.
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Product specifications
Category | Primary Antibodies |
Immunogen Target | Cellular Tumor Antigen P53 (TP53) |
Host | Rabbit |
Reactivity | Human |
Recommended Dilution | WB: 1/1000, IF/ICC: 1/100. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Biotin |
Purification | Peptide Affinity Purified |
Size 1 | 100 µg |
Tested Applications | WB, IF/ICC |
Buffer | PBS, 50% glycerol, 0.09% sodium azide. |
Availability | Shipped within 5-12 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | P04637 |
Gene ID | 7157 |
NCBI Accession | NP_000537.3 |
Background | Antibody anti-TP53 |
Status | RUO |
Note | Concentration: 1 mg/ml - |
Descripción
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anti- TP53 antibody
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21(lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2(PubMed:24051492).
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