Cellular Tumor Antigen P53 (TP53) Antibody (Biotin)

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637€ (100 µg)

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935106861
info@markelab.com
name
Cellular Tumor Antigen P53 (TP53) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx446375
tested applications
WB, IF/ICC

Description

p53 Antibody (Biotin) is a Rabbit Polyclonal against p53.

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Product specifications

CategoryPrimary Antibodies
Immunogen TargetCellular Tumor Antigen P53 (TP53)
HostRabbit
ReactivityHuman
Recommended DilutionWB: 1/1000, IF/ICC: 1/100. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationBiotin
PurificationPeptide Affinity Purified
Size 1100 µg
Tested ApplicationsWB, IF/ICC
BufferPBS, 50% glycerol, 0.09% sodium azide.
AvailabilityShipped within 5-12 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP04637
Gene ID7157
NCBI AccessionNP_000537.3
BackgroundAntibody anti-TP53
StatusRUO
NoteConcentration: 1 mg/ml -

Descripción

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anti- TP53 antibody

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21(lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2(PubMed:24051492).

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