TP53 Antibody is a Rabbit Polyclonal antibody against TP53. This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity.
Primary Antibodies
Polyclonal
Human, Mouse, Rat
Cellular Tumor Antigen P53 (TP53)
Rabbit
Unconjugated
Liquid
WB, IHC, IF/ICC, IP
Purified by affinity chromatography.
PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
20 µl
50 µl
100 µl
200 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
TP53
No
Shipped within 5-10 working days.
NP_000537.3
This product is for research use only.
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circum...
Precio a consultar
Ver másTP53 Antibody is a Rabbit Polyclonal antibody against TP53. This gene encodes a tumor suppressor protein containing tran...
175€ (20 µl)
Ver másTP53 Antibody is a Rabbit Polyclonal antibody against TP53. This gene encodes tumor protein p53, which responds to diver...
175€ (20 µl)
Ver más