Cell Adhesion Molecule 4 (CADM4) Antibody
364€ (100 µg)
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935106861
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name
Cell Adhesion Molecule 4 (CADM4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx231192
tested applications
ELISA, WB
Description
CADM4 Antibody is a Rabbit Polyclonal against CADM4.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cell Adhesion Molecule 4 (CADM4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8NFZ8 |
| Gene ID | 199731 |
| OMIM | 609744 |
| Alias | NECL4,TSLL2,IGSF4C,Necl-4,synCAM4,TSLC1-like protein 2,Nectin-like protein 4,Immunoglobulin superfamily member 4C |
| Background | Antibody anti-CADM4 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
CADM4, also known as SynCAM4 or nectin-like molecule 4 (Necl-4), is a member of the immunoglobulin superfamily and plays a critical role in cell-cell adhesion, particularly in epithelial and nervous tissues. It mediates both homophilic and heterophilic interactions, contributing to cellular polarity, tight junction formation, and signal transduction. CADM4 is expressed in a wide range of tissues, including the prostate, brain, and skin, where it is involved in maintaining epithelial integrity and regulating cell proliferation. Dysregulation of CADM4 is associated with tumorigenesis, as its downregulation has been observed in various cancers, including lung, prostate, and bladder cancers, suggesting its role as a tumor suppressor. It interacts with intracellular scaffolding proteins and cytoskeletal regulators, enabling its involvement in signaling pathways that influence cell migration and invasion. CADM4's extracellular domains mediate adhesion, while its intracellular domains anchor to cytoskeletal components, reinforcing its structural and signaling roles. Emerging research indicates that CADM4 may also influence immune responses and neuronal synaptic organization, highlighting its diverse functional significance.
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