Cell Adhesion Molecule 3 (CADM3) Antibody
221€ (50 µg)
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Name
Cell Adhesion Molecule 3 (CADM3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx329660
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
CADM3 Antibody is a Rabbit Polyclonal against CADM3.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Cell Adhesion Molecule 3 (CADM3) Immunogen: Synthesized peptide derived from the internal region of human IGSF4B. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | ELISA: 1/5000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8N126 |
| Gene ID | 57863 |
| NCBI Accession | NP_001120645.1, NM_001127173.2 |
| OMIM | 609743 |
| Alias | BIgR,NECL1,TSLL1,CMT2FF,IGSF4B,Necl-1,synCAM3,TSLC1-like protein 1,Nectin-like protein 1,Immunoglobulin superfamily member 4B,Brain immunoglobulin receptor |
| Background | Antibody anti-CADM3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CADM3, also known as SynCAM3 or nectin-like molecule 1 (Necl-1), is a neural cell adhesion molecule critical for axon-dendrite interactions, synaptic formation, and neural development. It is highly expressed in the nervous system, particularly in the brain, where it mediates the formation and maintenance of synaptic connections. CADM3 plays a crucial role in axon guidance and fasciculation, processes that are essential for proper neural circuit assembly during development. It facilitates both homophilic and heterophilic interactions with other adhesion molecules, contributing to the establishment of synaptic specificity and organization. CADM3 interacts with intracellular scaffolding proteins and signaling pathways to regulate actin cytoskeletal dynamics and intracellular signaling. Mutations or altered expression of CADM3 have been associated with neurodevelopmental disorders and cognitive deficits, highlighting its importance in brain function. Structurally, CADM3 contains extracellular Ig-like domains responsible for its adhesive properties and intracellular domains that anchor to the cytoskeleton and signaling complexes. CADM3's functions extend beyond the nervous system, as it is also expressed in epithelial tissues, where it contributes to cellular polarity and adhesion. Its role in tumor suppression has been explored, with evidence suggesting that CADM3 downregulation enhances tumor cell invasiveness and metastasis.
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