Adhesion G Protein-Coupled Receptor E6 (ADGRE5) Antibody (FITC)

Este producto es parte de ADGRE - Adhesion G protein-coupled receptor E
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364€ (100 tests)

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935106861
info@markelab.com
name
Adhesion G Protein-Coupled Receptor E6 (ADGRE5) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx139345
tested applications
FCM

Description

Adhesion G Protein-Coupled Receptor E5 (ADGRE5) Antibody is a Mouse Monoclonal against Adhesion G Protein-Coupled Receptor E5 (ADGRE5).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Adhesion G Protein-Coupled Receptor E5 (ADGRE5)
Host
Mouse
Reactivity
Human
Recommended Dilution
FCM: 20 µl/100 µl of whole blood or 106 cells. Optimal dilutions/concentrations should be determined by the end user.The content of a vial (2 ml) is sufficient for 100 tests.
Clonality
Monoclonal
Conjugation
FITC
Isotype
IgG1
Clone ID
H136
Size 1
100 tests
Tested Applications
FCM
Buffer
Stabilizing PBS solution containing 15 mM sodium azide.
Availability
Shipped within 5-12 working days.
Storage
Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze.
Dry Ice
No
UniProt ID
P48960
Gene ID
976
Alias
ADGRE5,CD97,BL-Ac (F2),CD97,TM7LN1
Background
Antibody anti-ADGRE5
Status
RUO

Descripción

Adhesion G protein-coupled receptor E5 (ADGRE5), also known as CD97, is a member of the adhesion GPCR family and plays an essential role in cell-cell and cell-matrix interactions. ADGRE5 is highly expressed in immune cells, including macrophages, neutrophils, and T-cells, as well as in endothelial and epithelial cells, where it mediates adhesion, migration, and cellular activation. It is a heterodimeric receptor that interacts with extracellular matrix proteins and cellular ligands such as CD55 (decay-accelerating factor), enabling immune surveillance and inflammation regulation. ADGRE5 is upregulated during inflammation, infection, and cancer progression, contributing to leukocyte recruitment, angiogenesis, and metastasis. Dysregulation of ADGRE5 is associated with autoimmune diseases, such as rheumatoid arthritis and inflammatory bowel disease, and its expression levels are linked to tumor aggressiveness in cancers like glioblastoma and colorectal cancer. Therapeutic targeting of ADGRE5 is being explored as a strategy to modulate immune responses and inhibit tumor metastasis by disrupting its signaling pathways and ligand interactions.

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This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19.

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