CD73 Antibody
91€ (25 µg)
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935106861
info@markelab.com
name
CD73 Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx228772
tested applications
IHC, FCM
Description
CD73 Antibody is a Mouse Monoclonal Antibody against CD73.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CD73 |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Size 1 | 25 µg |
| Size 2 | 100 µg |
| Size 3 | 1 mg |
| Tested Applications | IHC, FCM |
| Buffer | PBS with 0.05% Proclin300. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Do not freeze. |
| Dry Ice | No |
| UniProt ID | Q61503 |
| Gene ID | 23959 |
| Alias | NT,En,NT5,NTE,eNT,CD73,E5NT,CALJA,5'-NT,5'-deoxynucleotidase,Ecto-5'-nucleotidase,IMP-specific 5'-nucleotidase,Thymidylate 5'-phosphatase |
| Background | Antibody anti-NT5E |
| Status | RUO |
Descripción
The NT5E gene encodes 5'-nucleotidase ecto, also known as CD73, a glycosylphosphatidylinositol (GPI)-anchored enzyme that is crucial in purinergic signaling. It catalyzes the hydrolysis of extracellular nucleotides into nucleosides, with a primary function of converting AMP (adenosine monophosphate) to adenosine. CD73 is expressed on a wide range of cell types, including endothelial cells, epithelial cells, fibroblasts, T cells, and tumor cells. It plays a fundamental role in regulating inflammation, vascular permeability, immune response, and tissue protection under stress conditions such as ischemia. Adenosine generated by CD73 is a potent signaling molecule that binds to adenosine receptors (A1, A2A, A2B, and A3) to mediate various physiological processes, including anti-inflammatory effects, vasodilation, and immunosuppression. In the immune system, CD73 suppresses pro-inflammatory responses and helps in the resolution of inflammation. This dual role makes NT5E a key molecule in both health and disease, especially in pathologies such as cancer, cardiovascular diseases, and chronic inflammatory disorders.
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