CD45RA Antigen / PTPRC (CD45RA) Antibody
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Description
CD45RA Antigen (CD45RA/PTPRC) Antibody is a Mouse Monoclonal antibody against CD45RA Antigen (CD45RA/PTPRC).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CD45RA Antigen / PTPRC (CD45RA) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Validated in IHC-F and IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified |
| Size 1 | 20 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08575 |
| Alias | LCA,LY5,B220,CD45,L-CA,T200,CD45R,GP180,IMD105,CD45,Leukocyte common antigen,Receptor-type tyrosine-protein phosphatase C |
| Background | Antibody anti-PTPRC |
| Status | RUO |
| Note | Concentration: 1.0 mg/ml - |
Descripción
PTPRC, also known as CD45, is a receptor-type tyrosine phosphatase primarily expressed in hematopoietic cells. It regulates antigen receptor signaling in lymphocytes by dephosphorylating inhibitory residues on Src family kinases such as Lck and Fyn. Structurally, PTPRC has an extracellular domain, a single transmembrane region, and two cytoplasmic phosphatase domains, with the first being catalytically active. It is critical for T-cell and B-cell activation, development, and immune response regulation. Mutations in PTPRC are linked to severe immunodeficiency disorders, including SCID, and its overexpression is associated with autoimmune diseases and leukemia.
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