CD45RA Antigen (CD45RA/PTPRC) Antibody (APC)
429€ (100 tests)
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935106861
info@markelab.com
name
CD45RA Antigen (CD45RA/PTPRC) Antibody (APC)
category
Primary Antibodies
provider
Abbexa
reference
abx139832
tested applications
FCM
Description
CD45RA Antibody is a Mouse Monoclonal against CD45RA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CD45RA Antigen (CD45RA/PTPRC) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | FCM: 10 µl/100 µl of whole blood or 106 cells. Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | APC |
| Isotype | IgG2b |
| Clone ID | G127 |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P08575 |
| Gene ID | 5788 |
| Alias | LCA,LY5,B220,CD45,L-CA,T200,CD45R,GP180,IMD105,CD45,Leukocyte common antigen,Receptor-type tyrosine-protein phosphatase C |
| Background | Antibody anti-PTPRC |
| Status | RUO |
Descripción
PTPRC, also known as CD45, is a receptor-type tyrosine phosphatase primarily expressed in hematopoietic cells. It regulates antigen receptor signaling in lymphocytes by dephosphorylating inhibitory residues on Src family kinases such as Lck and Fyn. Structurally, PTPRC has an extracellular domain, a single transmembrane region, and two cytoplasmic phosphatase domains, with the first being catalytically active. It is critical for T-cell and B-cell activation, development, and immune response regulation. Mutations in PTPRC are linked to severe immunodeficiency disorders, including SCID, and its overexpression is associated with autoimmune diseases and leukemia.
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