CD44 Antigen (CD44) Antibody

Este producto es parte de CD44 - CD44 molecule
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292.5€ (80 µl)

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935106861
info@markelab.com
name
CD44 Antigen (CD44) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx025270
tested applications
ELISA, WB, IHC, IF/ICC, FCM

Description

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.

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Product specifications

CategoryPrimary Antibodies
Immunogen TargetCD44 Antigen (CD44)
HostMouse
ReactivityHuman
Recommended DilutionWB: 1/2000, IHC-P: 1/25, IF/ICC: 1/10 - 1/50, FCM: 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
ClonalityMonoclonal
ConjugationUnconjugated
IsotypeIgG2a Kappa
PurificationPurified through a protein G column, followed by dialysis against PBS.
Size 180 µl
Size 2400 µl
FormLiquid
Tested ApplicationsELISA, WB, IHC, IF/ICC, FCM
BufferPBS containing 0.09% sodium azide.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP16070
Gene ID960
AliasIN blood group,LHR,MC56,MIC4,CDW44,CSPG8,H-CAM,HCELL,ECM-III,HUTCH-1,HUTCH-I,ECMR-III,Hermes-1,Epican,Extracellular matrix receptor III,GP90 lymphocyte homing/adhesion receptor
BackgroundAntibody anti-CD44
StatusRUO
NoteConcentration: 0.42 mg/ml -

Descripción

CD44 is a type I transmembrane glycoprotein and an important cell surface receptor involved in various physiological and pathological processes. It is expressed on a wide range of cells, including hematopoietic cells, epithelial cells, fibroblasts, endothelial cells, and neurons. CD44 plays a crucial role in cell-cell and cell-matrix interactions, facilitating processes such as cell adhesion, migration, proliferation, and differentiation. The most well-studied ligand of CD44 is hyaluronic acid (HA), a major component of the extracellular matrix (ECM), which mediates a variety of cellular responses. CD44 is implicated in numerous biological processes, including immune response modulation, tissue repair, inflammation, and cancer metastasis. The molecule is often referred to as a "stem cell marker" due to its elevated expression in several types of cancer stem cells.

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