CD2 Associated Protein (CD2AP) Antibody
312€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
CD2 Associated Protein (CD2AP) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx102326
Tested Applications
WB, IHC
Description
Polyclonal Antibody to CD2 Associated Protein (CD2AP).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: CD2 Associated Protein (CD2AP) Immunogen: CD2AP (Asp368-Leu623) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CD2AP, CMS |
| Background | Antibody anti-CD2AP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD2-associated protein (CD2AP) is a cytoskeletal adaptor protein that plays a crucial role in cellular signaling and structural organization, particularly in podocytes within the kidney glomerulus. CD2AP interacts with various proteins to regulate actin cytoskeleton dynamics, supporting cell morphology and adhesion. It is a scaffolding protein that links membrane proteins, such as nephrin and other slit diaphragm proteins, to intracellular signaling pathways, ensuring the integrity of the filtration barrier in the kidney. Dysfunctions or mutations in the CD2AP gene are strongly associated with proteinuric kidney diseases, including focal segmental glomerulosclerosis (FSGS). Beyond its role in the kidney, CD2AP is implicated in immune synapse formation due to its interaction with the CD2 receptor on T cells, facilitating immune cell communication. CD2AP's functions in vesicular trafficking and endocytosis are also essential for cellular homeostasis. This protein is increasingly studied in the context of neurodegenerative diseases, such as Alzheimer's disease, where it is believed to impact amyloid precursor protein processing and autophagy pathways.
Productos relacionados
CD2 Associated Protein (CD2AP) Antibody
CD2AP Antibody is a Rabbit Polyclonal Antibody against CD2AP.…
Ver producto