Prominin-1 (PROM1) Antibody (APC)
429€ (100 tests)
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Name
Prominin-1 (PROM1) Antibody (APC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx140541
Tested Applications
FCM
Description
Prominin-1 (PROM1) Antibody (APC) is a Mouse monoclonal antibody against Prominin-1 (PROM1).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Prominin-1 (PROM1) Immunogen: WERI-RB-1 retinoblastoma cell line. |
| Host | Mouse |
| Reactivity | Human |
| Detection Method | Laser Line: 633 Excitation/Emission: 651/660 |
| Assay Type | Concentration: 0.006 mg/ml |
| Recommended Dilution | FCM: 10 µl/100 µl of whole blood or 106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | APC |
| Isotype | IgG1 |
| Clone ID | H203 |
| Purification | Purified by size-exclusion chromatography. |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | PBS, pH 7.4, containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | O43490 |
| Gene ID | 8842 |
| Alias | RP41,AC133,CD133,MCDR2,STGD4,CORD12,PROML1,MSTP061,Prominin-like protein 1 |
| Background | Antibody anti-PROM1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Prominin-1 (PROM1), also known as CD133, is a transmembrane glycoprotein that plays a significant role in stem cell biology and cellular development. Widely recognized as a marker for stem and progenitor cells in various tissues, PROM1 is expressed on the apical surface of epithelial and hematopoietic stem cells. It participates in cellular differentiation and is crucial for maintaining the stem cell niche, with implications in tissue regeneration and repair. PROM1 has become a focus of research due to its role in cell signaling and its involvement in numerous developmental pathways, including those of the nervous system, retina, and digestive tract. Additionally, aberrant PROM1 expression is associated with cancer, specifically in cancer stem cells, and its presence is often used as a marker to identify cells with tumorigenic potential. PROM1’s relevance to cellular organization and tissue homeostasis, along with its association with pathological conditions, makes it an important molecule in cell biology and oncology.
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