CCKBR-specific Antibody
377€ (100 µg)
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Name
CCKBR-specific Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx231378
Tested Applications
ELISA, WB, IF/ICC
Description
CCKBR-specific Antibody is a Rabbit Polyclonal against CCKBR-specific.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: CCKBR-specific Immunogen: cholecystokinin B receptor |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 64 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P32239 |
| Gene ID | 887 |
| OMIM | 118445 |
| Alias | CCKBR,CCK2 receptor,CK-B receptor,cholecystokinin-2 receptor ,CHOLREC,gastrin/cholecystokinin type B receptor,CCK-B/gastrin receptor,CCK-2R,CCK-B,CCK2R,GASR |
| Background | Antibody anti-CCKBR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CCKBR, also known as CCK2R, is a G protein-coupled receptor (GPCR) that binds both gastrin and cholecystokinin (CCK) peptides, playing critical roles in gastrointestinal function and brain signaling. It is expressed in the stomach, pancreas, brain, and certain tumors. In the gastrointestinal system, CCKBR regulates gastric acid secretion by stimulating parietal cells and promotes gastric mucosal growth, supporting digestive processes. In the central nervous system, CCKBR is involved in modulating anxiety, pain, and satiety through interactions with neurotransmitter systems. Its activation triggers pathways like phospholipase C (PLC), calcium mobilization, and MAPK signaling, leading to cellular proliferation, enzyme secretion, and neuronal modulation. CCKBR is highly implicated in gastric and pancreatic cancers, where gastrin-mediated activation enhances cell proliferation, survival, and tumor progression. Overexpression of CCKBR has been observed in gastric adenocarcinomas, making it a potential therapeutic target. Additionally, dysregulation of CCKBR signaling contributes to gastrointestinal disorders, including peptic ulcers and Zollinger-Ellison syndrome, characterized by excessive gastrin production. CCKBR is also being explored in neuropsychiatric research for its roles in anxiety and pain modulation. Overall, CCKBR regulates digestive and neuronal processes but contributes to disease progression when overexpressed or dysregulated.
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