CCKAR-specific Antibody
364€ (100 µg)
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935106861
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name
CCKAR-specific Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx231377
tested applications
ELISA, IHC
Description
CCKAR-specific Antibody is a Rabbit Polyclonal against CCKAR-specific.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CCKAR-specific |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P32238 |
| Gene ID | 886 |
| Alias | CCKAR,CCK-1R,CCK-A,CCK1-R,CCK1R,CCKRA,CCK1-R,cholecystokinin receptor type A,cholecystokinin-1 receptor |
| Background | Antibody anti-CCKAR |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
CCKAR is a G protein-coupled receptor (GPCR) predominantly expressed in the gastrointestinal tract, pancreas, and brain, where it binds the peptide hormone cholecystokinin (CCK) with high affinity. It regulates digestive processes by stimulating gallbladder contraction, pancreatic enzyme secretion, and gastric motility. In the brain, CCKAR is involved in satiety signaling, regulating appetite and feeding behavior by modulating neuronal pathways in the hypothalamus and brainstem. Its activation triggers downstream signaling pathways such as phospholipase C (PLC), calcium mobilization, and protein kinase C (PKC), leading to cellular responses like smooth muscle contraction and enzyme secretion. CCKAR is implicated in metabolic disorders, including obesity, where dysregulated signaling contributes to appetite dysregulation and energy imbalance. It also plays a role in anxiety and mood disorders, as CCK signaling interacts with neurotransmitter systems like dopamine and serotonin. In cancer, CCKAR overexpression has been observed in pancreatic and gastrointestinal cancers, where it enhances cell proliferation and survival. Pharmacological targeting of CCKAR is being explored for obesity, gastrointestinal disorders, and certain cancers. Overall, CCKAR is essential for gastrointestinal function, appetite regulation, and metabolic homeostasis.
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