Catenin Beta-1 (CTNNB1) Antibody

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Description
Catenin Beta-1 (CTNNB1) Antibody is a monoclonal Nanobody expressed in CHO cells for the detection of Human CTNNB1.
Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | Catenin Beta-1 (CTNNB1) |
Host | CHO cells |
Reactivity | Human |
Clonality | Monoclonal |
Conjugation | Unconjugated |
Isotype | VHH-His |
Clone ID | U746 |
Purity | > 95% (SDS-PAGE) |
Purification | Purified by Protein A/G affinity chromatography. |
Size 1 | 100 µg |
Size 2 | 1 mg |
Form | Liquid |
Tested Applications | ELISA |
Buffer | 0.01 M PBS, pH 7.4. |
Availability | Shipped within 5-12 working days. |
Storage | Store at 4 °C if the entire vial will be used within 1 week. Aliquot and store at -20 °C or -80 °C for long-term storage. Avoid repeated freeze-thaw cycles. |
Dry Ice | No |
UniProt ID | P35222 |
Gene ID | 1499 |
NCBI Accession | NP_001091679.1 |
Background | Antibody anti-CTNNB1 |
Status | RUO |
Note | Concentration: 1 mg/ml - |
Descripción
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The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
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