Caspase Recruitment Domain Family Member 8 (CARD8) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
CARD8 Antibody is a Rabbit Polyclonal against CARD8.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Caspase Recruitment Domain Family Member 8 (CARD8) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y2G2 |
| Gene ID | 22900 |
| Alias | CARDINAL,DACAR,DAKAR,NDPP,NDPP1,TUCAN,CARD-inhibitor of NF-kappa-B-activating ligand |
| Background | Antibody anti-CARD8 |
| Status | RUO |
Descripción
CARD8 is another member of the CARD protein family, involved in immune response regulation, particularly in the activation of inflammatory pathways. It contains a caspase recruitment domain (CARD), which is crucial for its role in signal transduction. CARD8 is involved in the regulation of the inflammasome, a complex that mediates the activation of caspase-1, leading to the production of pro-inflammatory cytokines such as IL-1β and IL-18. This protein is particularly important for detecting pathogens and cellular damage, promoting an appropriate inflammatory response. However, CARD8 can also regulate immune responses to prevent excessive inflammation, which is implicated in various chronic inflammatory diseases and autoimmune conditions. Research into CARD8 focuses on its role in diseases such as inflammatory bowel disease (IBD) and rheumatoid arthritis, where abnormal inflammasome activation is observed.
Related Products
CARD8 antibody
Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.
Ver Producto
Caspase Recruitment Domain Family Member 8 (CARD8) Antibody
CARD8 Antibody is a Rabbit Polyclonal antibody against CARD8. The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq].
Ver Producto
Caspase Recruitment Domain Family Member 8 (CARD8) Antibody
Caspase Recruitment Domain Family, Member 8 Antibody is a Rabbit Polyclonal antibody against Caspase Recruitment Domain Family, Member 8.
Ver Producto