Caspase Recruitment Domain Family Member 8 (CARD8) Antibody

Background

CARD8 is another member of the CARD protein family, involved in immune response regulation, particularly in the activation of inflammatory pathways. It contains a caspase recruitment domain (CARD), which is crucial for its role in signal transduction. CARD8 is involved in the regulation of the inflammasome, a complex that mediates the activation of caspase-1, leading to the production of pro-inflammatory cytokines such as IL-1β and IL-18. This protein is particularly important for detecting pathogens and cellular damage, promoting an appropriate inflammatory response. However, CARD8 can also regulate immune responses to prevent excessive inflammation, which is implicated in various chronic inflammatory diseases and autoimmune conditions. Research into CARD8 focuses on its role in diseases such as inflammatory bowel disease (IBD) and rheumatoid arthritis, where abnormal inflammasome activation is observed.