Caspase Recruitment Domain Family Member 11 (CARD11) Antibody

Background

CARD11, also known as CARMA1 (Caspase Recruitment Domain-Containing Membrane-Associated Protein 1), is a critical protein in the immune system, particularly in T-cell receptor (TCR) and B-cell receptor (BCR) signaling. It acts as an adaptor protein, linking upstream receptor activation to downstream signaling pathways, including the NF-κB pathway. NF-κB activation plays an essential role in the immune response, cell survival, and inflammation. CARD11 is crucial in immune cell activation, differentiation, and the production of pro-inflammatory cytokines. Mutations or dysregulation of CARD11 can result in immune system disorders, including lymphomas, and are implicated in autoimmune diseases such as systemic lupus erythematosus (SLE). Studies of CARD11's role in immune cell signaling have made it a potential therapeutic target for regulating immune responses and treating inflammatory or autoimmune diseases.