Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 (CEACAM1) Antibody
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Description
CEACAM1 Antibody is a Rabbit Polyclonal against CEACAM1.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 (CEACAM1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/1000 - 1/5000, WB: 1/500 - 1/2000, IHC: 1/15 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P13688 |
| Gene ID | 634 |
| Alias | BGP,BGP1,BGPI,BGP-1,CD66a,Carcinoembryonic antigen-related cell adhesion molecule 1 |
| Background | Antibody anti-CEACAM1 |
| Status | RUO |
Descripción
CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1) is a member of the CEA (carcinoembryonic antigen) family within the immunoglobulin superfamily (IgSF). This molecule plays a central role in intercellular adhesion, immune regulation, and tumor biology. CEACAM1 is highly expressed on various cell types, including epithelial cells, endothelial cells, leukocytes, and certain tumor cells. It is also involved in diverse physiological processes such as cellular differentiation, proliferation, angiogenesis, and immune response modulation. CEACAM1's expression is tightly regulated, often seen in specific tissues such as the liver, kidneys, and lungs, and it is known to be upregulated during certain immune responses and pathological conditions like inflammation and cancer. This protein has become a subject of interest due to its diverse biological functions, particularly in immune regulation and its role in tumor suppression or tumor progression, depending on the cellular context.
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Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 (CEACAM1) Antibody
CEACAM1 Antibody is a Rabbit Polyclonal antibody against CEACAM1. This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.
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