Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5) Antibody Pair

Product specifications

Antibody Pairs

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5)

Human

Capture: Mouse  Monoclonal
Detection:  Mouse  Monoclonal (Biotin)

Sandwich

39 pg/ml - 2500 pg/ml

Dilute the Capture Antibody 125-fold with Coating Buffer.  Dilute the Biotin-Conjugated Detection Antibody 200-fold with Detection Antibody Diluent.  Optimal dilutions/concentrations should be determined by the end user.

5 × 96 tests

10 × 96 tests

Standard: Lyophilized--Liquid (Capture Antibody and Detection Antibody)
Reconstitute the standard with Standard Diluent. The volume, and therefore standard concentration, should be determined by the end user. The recommended reconstitution volume is 1.0 ml for a standard curve range of 39 pg/ml - 2500 pg/ml.

ELISA

The Capture and Detection Antibody both contain 0.1% sodium azide.

Shipped within 5-20 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

P06731

1048

CEA,CD66eMeconium antigen 100,Carcinoembryonic antigen

Antibody Pair for CEACAM5

RUO

This antibody pair contains ( 5 x 96 det):    Detection:  50 µg  Capture:  200 µg  Standard:  2 µg
This product is for research use only.

Descripción

CEACAM5, also known as carcinoembryonic antigen (CEA), is a glycoprotein member of the immunoglobulin superfamily that plays a prominent role in cell adhesion, immune modulation, and intercellular signaling. It is highly expressed in epithelial tissues and is overexpressed in various cancers, including colorectal, pancreatic, and lung cancers, where it is used as a tumor marker for diagnosis, prognosis, and monitoring therapeutic responses. CEACAM5 mediates homophilic and heterophilic adhesion, influencing cellular aggregation, invasion, and metastasis. It interacts with other CEACAM family members and cell surface receptors to regulate signaling pathways involved in cell proliferation, migration, and immune evasion. Structurally, CEACAM5 contains multiple immunoglobulin-like domains, a glycosylphosphatidylinositol (GPI) anchor, and extensive glycosylation sites that contribute to its functional diversity. In cancer, CEACAM5 promotes tumor progression by enhancing adhesion to extracellular matrix components and modulating immune responses, such as inhibiting T-cell activation. Therapeutic strategies targeting CEACAM5, including monoclonal antibodies and vaccines, are under development to exploit its role as a biomarker and driver of tumor progression. CEACAM5 also plays roles in physiological processes like epithelial cell polarity and tissue homeostasis, reflecting its multifaceted importance.

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