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Canine MMP2(Matrix metalloproteinase-2) ELISA Kit
proveedor
FineTestreference
ECA0047Tested Applications
reactivity
caninestatus
RUOclonality
Background
MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. Matrix metalloproteinase-2 (MMP-2), also referred to as gelatinase A, is an enzyme encoded by the MMP2 gene in humans. MMP-2 exhibits a wide range of substrates, including gelatin, collagen types I, II, III, IV, Vii, and X. It has been implicated in various aspects of cancer, including therapy, angiogenesis, and cell signaling. Among its aliases are CLG4, Gelatinase A, 72kDa Gelatinase, 72kDa Type IV Collagenase, Matrix Metalloproteinase-II, and Collagenase Type IV-A.
Background
MMPs son secretadas por diversos tejidos conectivos y células proinflamatorias. Normalmente, estas enzimas exhiben una expresión mínima en circunstancias fisiológicas normales. Las MMP asumen un papel fundamental en diversos procesos celulares, incluida la proliferación, migración, diferenciación, angiogénesis, apoptosis e inmunidad celular. Comparten una estructura de dominio común, que consta de tres componentes clave. El primero es el propéptido, que requiere eliminación para activar la enzima. A continuación, está el dominio catalítico, que presenta un interruptor de cisteína, donde un residuo de cisteína interactúa con el zinc, y el dominio C-terminal similar a hemopexina está unido al dominio catalítico a través de una región bisagra flexible. MMP-2, también conocida como gelatinasa A, es una enzima codificada por el gen MMP2. En humanos. MMP-2 exhibe una amplia gama de sustratos, incluidos gelatina, colágeno de tipo I, II, III, IV, Vii y X. Se ha implicado en diversos aspectos del cáncer, incluida la terapia, la angiogénesis y la señalización celular. Entre sus alias se encuentran CLG4, Gelatinasa A, Gelatinasa de 72 kDa, Colagenasa Tipo IV de 72 kDa, Metaloproteinasa de Matriz-II y Colagenasa Tipo IV-A.
Características del producto
category
ELISA Kits
reactivity
canine
test range
31.25-2000pg/ml
assay type
Sandwich ELISA, Double Antibody
assay data
Quantitative
detection method
Colorimetric
sample type
Busacar en las instrucciones
size 1
96T
alias
72 kDa type IV collagenase|72 kDa gelatinase|Gelatinase A|CLG4A
storage
2-8 °C for 6 months
or code
MMP2
uniprot id
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